alpha-Maleinimido-omega-carboxy succinimidyl ester poly(ethylene glycol) (PEG-MW 3.000 Dalton) - Names and Identifiers
alpha-Maleinimido-omega-carboxy succinimidyl ester poly(ethylene glycol) (PEG-MW 3.000 Dalton) - Physico-chemical Properties
Molecular Formula | C22H31N3O9
|
Molar Mass | 481.49624 |
Storage Condition | -20°C |
alpha-Maleinimido-omega-carboxy succinimidyl ester poly(ethylene glycol) (PEG-MW 3.000 Dalton) - Introduction
NHS-PEG-MAL(NHS-PEG-MAL) is a commonly used chemical reagent. It is composed of the active ester compound N-hydroxysuccinimide (NHS) combined with polyethylene glycol (PEG) group and maleimide (MAL) group. Its nature is as follows:
1. active properties: NHS-PEG-MAL has activated affinity groups, which can react rapidly with biological molecules containing functional groups (such as amino groups, sulfhydryl groups, etc.).
2. solubility: NHS-PEG-MAL soluble in water, but also soluble in some organic solvents (such as DMF, DMSO, etc.).
The main uses of NHS-PEG-MAL are as follows:
1. cross-linking reagent: NHS-PEG-MAL can be used to cross-link with proteins, antibodies and other biological macromolecules to prepare polymer composites with improved stability and solubility.
2. Targeted drug delivery: NHS-PEG-MAL can be used to modify drug carriers (such as nanoparticles, microspheres, etc.) to increase their stability and targeting in vivo.
3. Biosensors: NHS-PEG-MAL can be used to prepare biosensors for detecting and analyzing the presence and concentration of biomolecules.
The preparation of NHS-PEG-MAL is generally achieved by chemical synthesis. Specifically, NHS, PEG and MAL are reacted according to a certain molar ratio, and subjected to deionized water treatment and purification steps to prepare NHS-PEG-MAL.
Pay attention to the following safety information when using the NHS-PEG-MAL:
1. Avoid contact with skin and eyes: NHS-PEG-MAL are chemical reagents, direct contact with skin and eyes should be avoided. In case of contact, rinse immediately with plenty of water and seek medical attention.
2. storage note: NHS-PEG-MAL should be stored in a dry, cool, dark place, avoid direct sunlight and high temperature.
3. Pay attention to ventilation during operation: When operating NHS-PEG-MAL, please ensure a well-ventilated working environment to avoid inhaling aerosols or dust.
4. Comply with laboratory specifications: When using NHS-PEG-MAL, you should comply with laboratory operating specifications and related regulations to ensure safety and correct operation.
Last Update:2024-04-09 21:21:28